Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration (Small 47/2021)

TAAVI LEHTO Delivery of nucleic acids by cell-penetrating peptides: application in modulation of gene expression

Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, an...

Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small Arginine-Rich Cell-Penetrating Peptide (R/W)9

Peptide nucleic acids (PNAs) are very attractive antisense and antigene agents, but these molecules are not passively taken into cells. Here, using a functional cell assay and fluorescent-based methods, we investigated cell uptake and antisense activity of a tridecamer PNA that targets the HIV-1 polypurine tract sequence delivered using the arginine-rich (R/W)9 peptide (RRWWRRWRR). At micromola...

Synthesis and Application of Functional Nucleic Acids

1 Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20, Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan 2Physics Department, Technische Universität München, Am Coulombwall 4a, 85748 Garching, Germany 3Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, New Delhi 110 007, India 4Departmen...

Metabolism of Nucleic Acids during Regeneration of Wound Tissue*

The formation of regenerating wound tissue involves not only production of new cells but also synthesis of relatively large amounts of protein (l-5). From these facts, it may be inferred that while this new tissue is being formed, nucleic acid metabolism is probably different from that observed in normal animals. There has been some indication that this may be the situation for ribonucleic acid...